energenesis

The most powerful mitochondria and energy support supplement ever created.

Energenesis
Energenesis

The most powerful mitochondria and energy support supplement ever created.

The Big Key to REAL Energy Enhancement Isn't Sugar and Stimulants - it's Optimizing Your Mitochondria

Virtually all of the energy that powers all the trillions of cells in your body comes from your mitochondria.

Mitochondria

The Powerhouses of the cell.

Mitochondria are the absolute most critical physiological system involved in our energy levels. If you are dealing with fatigue, that is almost certainly a sure sign that your mitochondria are not functioning well. Here’s the problem: As you age, your mitochondria become damaged and dysfunctional. And they even shrink in size

Think of how a muscle shrinks or atrophies if it’s in a cast – the same thing happens to our mitochondria, our energy generators over time. Research has shown that for most people, from the age of 20-40, their mitochondrial capacity (the ability of our cells to produce energy) decreases by HALF. And then, from 40-70, it decreases by another HALF!

Up to Age 20
Age 20 - 40
Age 40 - 70

As a result, the energy your mitochondria produce naturally decreases over time, reducing your health and longevity — and ultimately, causing fatigue.

On top of that, stressors in our life — from psychological stress, to environmental toxins (like heavy metals and air pollutants), to a poor diet, to poor gut health, to chronic inflammation — all-cause mitochondrial damage, dysfunction and shut down (they shift out of energy mode into a cell protection response).

Research is now showing that these three things — the loss of mitochondria, the damage/dysfunction of mitochondria, and the shut down of mitochondria — are the primary factors that drive low energy levels.

In other words, if you’ve got low energy levels, it likely simply means that your mitochondria have become weak, damaged, dysfunctional, and switched off over time.

Here’s the spectrum of energy, so you can visualize where you are on this continuum.

Where are you on this spectrum?

If you’d like more energy, here’s what you need to know…

Supporting your mitochondrial health is the single most important thing you can do to help overcome fatigue and increase your energy levels.

There are 6 key pathways you need to build if you really want to build big healthy mitochondria that pump out energy all day long.

  • You Need BIGGER Mitochondria. Building the size of your mitochondria so they can produce more energy is one of the most important factors in increasing energy levels over time.
  • You Need MORE Mitochondria (i.e. Mitochondrial Biogenesis). The more mitochondria you have, the bigger your “cellular engine” grows, the more energy you’re able to produce. Several ingredients in this list can actually stimulate this process of mitochondrial biogenesis – allowing your body to build more mitochondria from scratch.
  • It’s VITAL to Repair and Protects Your Cell Membranes. Research has shown that one of the most potent ways to improve energy levels is to repair the physical membranes of your mitochondria. (Several of the ingredients on this list can do this, but #1 and #2 are especially powerful).
  • You Need Cofactors Involved Mitochondria Energy Production. These are substances that facilitate the process of mitochondria producing cellular energy.
  • You Need To Recharge NAD+ Levels. NAD+ is a critical regulator of mitochondrial energy production. Several key compounds in this list directly help rebuild our body’s supply of NAD+ (like #13, #20, #23, and #24).
  • You Need To Build Up Your Mitochondrial Internal Defense System (a.k.a. The NRF2 Pathway and the A.R.E.) People speak about the importance of antioxidants, but don’t realize that our cells’ internal antioxidant defense system is hundreds of times more powerful and more important. Several of the compounds in this list don’t just work as antioxidants, but even better, they build up the body’s internal cellular/mitochondrial antioxidant defense system — that makes our mitochondria more able to deal with stressors and protect themselves from damage, which ultimately means that instead of getting shut down, they stay in High Energy Mode pumping out energy.

Now that you understand all the background of how to build a REAL ENERGY at the cellular level, let’s get into the most powerful compounds for building your mitochondria and your energy levels!

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Energenesis: 1 Month Supply
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Energenesis Ingredients

What's Inside The Most Powerful Energy Supplement Ever Created

Mitochondrial Membrane Support Complex

NT Factor Phospholipids

NTFactor® is a digestion-resistant phospholipid complex that supplies the materials necessary to repair and regenerate damaged cell membranes directly to mitochondria, a treatment called lipid replacement therapy [1]

By supplying the bioactive phospholipids that mitochondria require to naturally replace damaged membrane components, NTFactor® is able to regenerate dysfunctional mitochondria, increase energy production, and enhance the energy levels of those using it.

Numerous studies have shown that NTFactor® reduces fatigue by 24–43 percent among those with chronic fatigue syndrome or conditions associated with fatigue, like general aging, obesity, lyme disease, and Gulf War Illness [2]. In older adults, NTFactor® restored mitochondrial function to a level matching healthy 29 year-olds [3].

Astaxanthin

Astaxanthin is one of the most powerful membrane-specific antioxidants in existence. Not only is it 30–85 percent more potent than vitamin E and carotenoids like β-carotene, lycopene, and lutein [4], but it has a unique polar structure that allows it to cross through, protect, and stabilize the entire mitochondrial membrane [5].

Due to astaxanthin’s consistent and powerful ability to prevent oxidative damage and dysfunction to mitochondria [6–8], some researchers have even determined it to be “mitochondria-targeted antioxidant” [9].

Interventions have shown that astaxanthin supplementation increases muscular strength and power output in fatigued adults [10], enhances muscular endurance and recovery in recreational athletes [11,12], and reduces muscle damage and oxidative stress in elite soccer players [13].

Mitochondrial Energy Production Cofactor Complex

Acetyl-L-Carnitine

Acetyl-L-Carnitine (ALCAR) is a special form of carnitine that achieves two goals: (1) it supplies the carnitine your mitochondria need to produce energy, and (2) it provides an acetyl moiety that your mitochondria use to remain youthful and healthy.

The carnitine shuttle system is essential for bringing fatty acids into mitochondria to be used for energy production, and carnitine deficits (even mild ones) have been documented in those with chronic fatigue [14]. Moreover, over 20 percent of mitochondrial proteins rely on acetyl moieties to properly function, including those involved in antioxidant defenses and energy production [15,16].

For these reasons, some researchers have proposed that ALCAR should be considered a “mitochondrial rejuvenator” [17]. In chronically fatigued older adults, ALCAR supplementation led to profound benefits to their wellbeing — a 24 percent increase in physical function and close to a whopping 50 percent reduction in mental fatigue, physical fatigue, and overall fatigue severity [18].

Creatine

Creatine is a molecule necessary for rapid and explosive energy production when energy needs cannot be immediately met by our mitochondria. Supplementation works by increasing the amount of available creatine within our muscles.

This not only increases muscular performance, but also helps stimulate mitochondrial energy production when faced with signals to do so (like being physically active) [24], enhance mitochondrial biogenesis and integrity [25], and protect mitochondria from oxidative damage [26,27].

Accordingly, creatine is one of the most extensively researched supplements for improving exercise performance, muscle strength, and power output in people of all ages [28–32].

Coenzyme Q10

Coenzyme Q10 (CoQ10) is an essential component of mitochondrial energy production, serving as both an antioxidant and an energy-transferring molecule. As such, deficits in CoQ10 will not only lead to a cessation of energy production, but also an increase in oxidative damage.

Individuals with chronic fatigue regularly show deficiencies in CoQ10 concentrations throughout the body [33], as do those with conditions in which fatigue is a common symptom, like fibromyalgia [34–36], those who have survived heart attacks or heart failure [37,38], and multiple sclerosis [39,40].

Supplementation with CoQ10 improves fatigue, autonomic nervous system activity (the part of the nervous system involved in rest and recovery), and biochemical parameters of mitochondrial energy production in those with chronic fatigue [41–44], and reduces general fatigue and oxidative stress in healthy adults [45,46].

Alpha-Lipoic Acid (ideally R-ALA)

Alpha-lipoic acid (ALA) is a mitochondrial molecule involved in energy metabolism and the antioxidant system. It is not only essential for mitochondria to create cellular energy, but also serves to function as an antioxidant, replenish other antioxidants, and stimulate the production of antioxidant enzymes like glutathione [47].

Accordingly, ALA has been heavily investigated as a mitochondrial rejunivator, able to help reverse age-related declines in mitochondrial energy production [48], particularly within the brian [49,50]

By improving mitochondrial function and protecting against oxidative stress, ALA has been shown to benefit metabolic health [51,52], as well as facilitate weight loss among those who are overweight [53–55].

ALA exists as either an S or R isomer, with unspecified ALA being a 50-50 ‘racemic’ solution of both. Most studies use the racemic solution, but only R-ALA has biological activity in the body and is more bioavailable [56], which is why we use it in Energenesis.

NAD+ Regeneration Complex

Taurine

Taurine is an omnipresent amino acid within the body, essential for the development and function of our cardiovascular, muscular, nervous, and ocular systems [57]. It’s also essential for mitochondrial energy production and protein synthesis [58,59]

The highest amounts of taurine are in tissues with huge energy requirements and a lot of mitochondria, such as the retina, nerves, kidney, heart, and skeletal muscle [60]. If mitochondria don’t have enough taurine, energy production decreases and oxidative stress increases [61].

Insufficient taurine has been implicated in numerous chronic disease states [62,63], and several clinical trials have shown that supplementing with taurine reduces oxidative stress and inflammation in those with metabolic dysfunction [64–66].

Additionally, a meta-analysis reported that taurine supplementation improved endurance exercise performance, particularly power output and the amount of time that people could run before exhaustion [67].

Magnesium

Magnesium is required for over 300 enzymes to function properly — muscle contractions, blood vessel regulation, insulin signaling, the synthesis of DNA and proteins, and nerve transmission all require magnesium [68].

One of the enzymes that relies on magnesium is ATP synthase, which is responsible for generating cellular energy (ATP) within mitochondria. Without magnesium, your mitochondria simply can’t function efficiently [69,70].

Energenesis provides two forms of magnesium, citrate and malate, which are both cofactors for mitochondrial energy production themselves.

B3 Variants (NMN, NR, Niacin & Niacinamide)

Niacin is an essential component of energy-carrying molecules within the mitochondria, all of which are derivatives of nicotinamide adenine dinucleotide (NAD+). NAD+ is important for energy production, mitochondrial function, and cellular repair processes.

The primary route of NAD+ synthesis is through something called the salvage pathway, in which niacinamide serves as the starting molecule. We can also make NAD+ from nicotinic acid using an alternative pathway, which is why we’ve included both forms in Energenesis to ensure that NAD+ generation is not being impeded by a simple vitamin insufficiency.

Mitochondrial Energy Production Cofactor Complex

Pomegranate

Pomegranate is a rich source of ellagitannins, potent antioxidant molecules that can be further metabolized into other antioxidant derivatives like ellagic acid and urolithins [71,72]. These substances have been heavily investigated for their mitochondrial and cardiovascular benefits.

Pomegranate ellagitannins and their derivatives have been shown to enhance mitochondrial function [73] and increase rates of mitophagy (mitochondria + autophagy) [74,75], which is a quality control pathway that preserves mitochondrial health by targeting damaged mitochondria for autophagic degradation, making anything that facilitates mitophagy absolutely vital for optimal health and disease prevention.

In recreational endurance athletes, supplementing with pomegranate extract for just two weeks increased the total time the athletes could cycle before complete exhaustion by 14 percent and increased the amount of time they could rely on their mitochondria to supply most of their energy by 10 percent [76].

Moreover, pomegranate supplementation has been shown to reduce blood lipid oxidation and the accumulation of plaque in arteries [77], particularly in people who have higher levels of oxidative stress [78,79].

Green Tea Catechins

Green tea (Camellia Sinensis) catechins are four phytochemical molecules, the most potent one being epigallocatechin-3-gallate (EGCG). It has been implicated in benefiting almost every organ system in the body in doses you can obtain easily from simply drinking green tea [87–89].

EGCG is neuroprotective [90,91], cardioprotective [92,93], anti-obesity [94–96], anti-carcinogenic [97,98], and anti-diabetic [99], all due primarily to its ability to stimulate mitochondrial biogenesis, enhance energy production, and protect mitochondria from oxidative stress [100,101].

Supplementation of EGCG plus resveratrol (another ingredient of Energenesis) has been shown to significantly increase mitochondrial function and the use of fatty acids for energy production [102], and several meta-analyses have concluded that EGCG reduces body weight and body fat [103–106], particularly abdominal fat [107]

Gynostemma

Gynostemma is a climbing vine native to SouthEast Asia and related to Panax Ginseng, containing many of the same bioactive molecules. Unlike ginseng, however, gynostemma also possesses an array of gypenosides that have been shown to upregulate several signaling molecule likes sirtuins and AMPK which facilitate mitochondrial function and biogenesis [108–110].

Clinical trials have shown that supplementation with gynostemma improves metabolic health through these mechanisms. A study of overweight men and women reported that supplementing with 450 mg of gynostemma daily for 12 weeks reduced total abdominal fat by 6%, visceral fat by 10%, and subcutaneous fat by 4% compared to a placebo [111].

Drinking 6 grams of gynostemma in the form of a tea lowered fasting glucose and insulin resistance each by 30% compared to a placebo after 12 weeks in adults with type 2 diabetes [112], and supplementing with 80 mL of gynostemma extract may improve liver health alongside dieting more than dieting alone in adults with fatty liver disease [113].

Ashwagandha (Shoden extract)

Ashwagandha (Withania somnifera) is a nightshade revered in Ayurvedic medicine for its physical- and mental-enhancing effects [114]. Today, it’s considered an adaptogen for similar reasons, able to increase a person’s resilience to stress and help reduce anxiety [115,116].

These effects are largely due to its constituent withanolide structures, which have several important neuroprotective effects within the brain, such as scavenging free radicals, reducing neuroinflammation, and promoting neurotransmitter signaling [117]. They also improve mitochondrial function and energy production [118].

In Energenesis, we use the most potent form of ashwagandha, a 35% withanolide concentrate called the Shoden extract. Just 240 mg of Shoden ashwagandha reduces stress and anxiety by 30% in mildly stressed adults [119], while a mere 60 mg can boost DHEA-S and testosterone by 15–18% in middle-aged men [120].

In another large randomized placebo-controlled trial of 150 men and women, supplementing 120 mg has been documented to improve physical and psychological quality of life by 8% and enhance sleep quality by 40% compared to placebo, including dramatically improving the time it took to fall asleep, total sleep time, and nightly awakenings [121].

Other studies have shown ashwagandha supplementation to reduce perceived stress, anxiety, and depression in mildly stressed healthy adults [122,123], adults battling chronic mental stress [124], and adults with an anxiety disorder [125].

Panax Ginseng

Panax ginseng has been used medicinally for thousands of years in China, Korea, and Japan to alleviate physical and mental fatigue. While there are several types of ginseng on the market, panax ginseng is considered the “true” ginseng.

At a fundamental level, panax ginseng works to protect mitochondria from oxidative damage and improve energy production under conditions of oxidative stress [126,127]. A systematic review and meta-analysis of five studies in chronic fatigue patients found significant benefits of ginseng supplementation for reducing fatigue severity [128], with reductions of 20 percent after one month not being uncommon [129,130].

PQQ (Pyrroloquinoline Quinone)

Pyrroloquinoline Quinone (PQQ) is a potent stimulator of pathways involved in mitochondrial biogenesis and antioxidant defenses [131,132]. In particular, it stimulates pathways shared by exercise training and is believed to potentiate and enhance activity-induced benefits on mitochondria [133].

Supplementation has been shown to reduce fatigue and increase vigor by 20 percent in adults complaining of poor sleep and energy levels, as well as improve mood, sleep quality, and overall quality of life [134]. In another study of healthy adults, PQQ reduced inflammation and improved markers of mitochondrial respiration [135].

Transparency on the Label

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What people say about Energenesis

I am a 72 year old female and I love, love, love Energensis. I have more sustained energy throughout the day and am actually getting my life back. I am doing things that haven't been able to do for 10 years. I also seem to have a much better attitude about life, my day, whatever."

Barbara F.

Just wanted to say I am absolutely blown away with Energenesis. Have had it for a couple weeks now, and my energy levels are already starting to feel like they were when I was a kid."

Kyle T.

The reason I'm writing is to thank you for Energenesis! I've just taken it a few times, but I'm already amazed by my increased energy & focus levels. This stuff is amazing...

Tyler Y.

Energenesis gave me my life back."

Denise P.

Introducing The Most Powerful Mitochondria and Energy Support Supplement Ever Created - Energenesis

I’m excited to announce that after nearly 2 years of development, my team and I have developed the most powerful mitochondrial energy supplement ever developed.

I say this definitively, because once you see the list of ingredients in this (it includes almost all the ingredients mentioned in the list above) and the fact that it has REAL effective doses of these ingredients (which no other manufacturer is doing), you’re going to be blown away…

Energenesis is the most powerful mitochondria-enhancing nutraceutical ever created!

Energenesis is the first non-stimulant energy formula that actually builds up your own body’s ability to produce energy!

Packed with a potent dose of a whopping 16 of the most powerful mitochondria-building ingredients in existence, Energenesis is a NEW, premium, scientifically-backed formula to re-awaken your body’s built-in energy system.

What makes Energenesis different?

Unlike previous generation “energy supplements,” it contains no stimulants, no caffeine, and no sugar. This isn’t about giving you a fake energy boost, while actually making your energy levels worse over time.

Energenesis builds REAL ENERGY!

This is not a supplement designed to fill to people’s desire for quick fixes and instant gratification through stimulants and temporary boosts of fake energy.

Energenesis is for people looking for REAL ANSWERS, who want to address ROOT CAUSES, and want to build real energy at the cellular level.

As a result, the energy your mitochondria produce naturally decreases over time, reducing your health and longevity — and ultimately, causing fatigue.

On top of that, stressors in our life — from psychological stress, to environmental toxins (like heavy metals and air pollutants), to a poor diet, to poor gut health, to chronic inflammation — all cause mitochondrial damage, dysfunction and shut down (they shift out of energy mode into a cell protection response).

Research is now showing that these three things — the loss of mitochondria, the damage/dysfunction of mitochondria, and the shut down of mitochondria — are the primary factors that drive low energy levels.

In other words, if you’ve got low energy levels, it likely simply means that your mitochondria have become weak, damaged, dysfunctional, and switched off over time.

Here’s the spectrum of energy, so you can visualize where you are on this continuum.

As you take Energenesis consistently over several weeks, it builds up your cellular engine, your mitochondria.

You may feel a slight energy boost from the very first time you take it, but what it’s really doing is steadily and sustainably re-charging and building up your mitochondria so that your body becomes capable of producing more energy on its own!

In short, Energenesis is a repair system for the natural process of dysfunctional energy producing cells. It acts by restoring your body’s ability to rely on itself for energy.

The old way to make an energy supplement was just about using caffeine, sugar and other stimulants to give a quick jolt. (While actually making you worse over time.)

We’re here to introduce the NEW way to make an energy supplement – by using the science of how to actually build up the body’s own production of cellular energy!

The Difference Between Caffeine/Stimulant "Energy" Supplements vs. Energenesis

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Energenesis: 1 Month Supply
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Energenesis: 3 Month Supply
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Energenesis is a next generation energy supplement

Remember the 6 key mechanisms you need to support optimal mitochondrial health:

  1. You need BIGGER Mitochondria
  2. You Need MORE Mitochondria (i.e. Mitochondrial Biogenesis)
  3. It’s VITAL to Repair and Protect Your Mitochondrial Membranes
  4. You NEED Cofactors Involved Mitochondrial Energy Production
  5. You Need to Recharge NAD+ Levels
  6. You Need to Build Up Your Mitochondrial Internal Defense System

This is EXACTLY what Energenesis is designed to do!

What's in Energenesis?

Energenesis is like a 5-star MEAL for your Mitochondria (LOADED with rare nutrients, energy boosters and powerful antioxidants, because your body needs a variety – each one works differently!) AND… we have gone to amazing lengths to source the highest quality ingredients, with unparalleled potency, purity, biological availability, and effectiveness…

If you want to see a breakdown of the exact ingredients and amounts, you can look in the right column of the image below…

It’s a potent cocktail of the most powerful mitochondrial regenerating ingredients designed to literally CHARGE your cells back up, so you can have the energy you had when you were young – ALL DAY ENERGY.

If you’ve been struggling with fatigue or low energy levels, it’s time to stop dragging yourself through the day with caffeine and stimulants…

It’s time to start building REAL ENERGY.

You can certainly use the information here to go out and buy all these compounds as separate supplements, but I strongly encourage you to simply get Energenesis. It’s obviously far more convenient to get everything in one formula rather than fiddling with 20 different bottles and 25 pills each day. Also, you don’t have to worry about dosing everything correctly.

And, on top of that, I’ve tried to make it a complete no brainer for you by making it way cheaper for you to order it this way (as opposed to buying 20+ different supplements).

Energenesis is simply the most powerful formula ever developed for that purpose.

We have it available in either 1, 3, or 5 bottle packages (obviously, the more you order, the cheaper it gets).

What people say about Energenesis

Energenesis has brought me to a higher level of competition this year in bike racing. I've been able to race again some really fast men and beat some of them...going to nationals in a few weeks since I'm feeling so good!"

Bonnie S.

I feel a definite improvement in my energy, mood, and even sleep, and also my capacity at the gym..."

Getty P.

...my brain fog has lifted."

Mary Ann C.

...loved it immediately. My energy was better and sustained throughout day and I look forward to it in the morning!"

Raquel F.

Decrease Brain Fog, and Improve Brain Energy, Focus, And Memory

Supercharge Your Mitochondria

Increase Your Physical Energy Levels

Energenesis

Enhance Your Stamina & Endurance

Improve Your Mood

Improve Your Brain Function & Focus

Get Your Energenesis Now!

Energenesis: 1 Month Supply
1 Month Supply

Energenesis

$119.00  $89.25
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(FREE shipping within the U.S.)*
*For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Energenesis: 3 Month Supply
3 Month Supply

Energenesis

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Energenesis: 1 Month Supply
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$119.00  $77.35

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Worldwide Shipping (FREE Shipping within the U.S.)* 
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References

  1. Nicolson GL, Ash ME. Lipid Replacement Therapy: a natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function. Biochim Biophys Acta. 2014;1838:1657–79.
  2. Nicolson GL, Rosenblatt S, de Mattos GF, Settineri R, Breeding PC, Ellithorpe RR, et al. Clinical Uses of Membrane Lipid Replacement Supplements in Restoring Membrane Function and Reducing Fatigue in Chronic Diseases and Cancer. Discoveries (Craiova). 2016;4:e54.
  3. Agadjanyan M, Vasilevko V, Ghochikyan A, Berns P, Kesslak P, Settineri RA, et al. Nutritional Supplement (NT FactorTM) Restores Mitochondrial Function and Reduces Moderately Severe Fatigue in Aged Subjects. J Chronic Fatigue Syndr. Taylor & Francis; 2003;11:23–36.
  4. Naguib YM. Antioxidant activities of astaxanthin and related carotenoids. J Agric Food Chem. 2000;48:1150–4.
  5. Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev. 2011;16:355–64.
  6. Kim SH, Kim H. Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review. Nutrients [Internet]. 2018;10. Available from: http://dx.doi.org/10.3390/nu10091137
  7. Yu T, Dohl J, Chen Y, Gasier HG, Deuster PA. Astaxanthin but not quercetin preserves mitochondrial integrity and function, ameliorates oxidative stress, and reduces heat-induced skeletal muscle injury. J Cell Physiol. 2019;234:13292–302.
  8. Krestinina O, Baburina Y, Krestinin R, Odinokova I, Fadeeva I, Sotnikova L. Astaxanthin Prevents Mitochondrial Impairment Induced by Isoproterenol in Isolated Rat Heart Mitochondria. Antioxidants (Basel) [Internet]. 2020;9. Available from: http://dx.doi.org/10.3390/antiox9030262
  9. Sztretye M, Dienes B, Gönczi M, Czirják T, Csernoch L, Dux L, et al. Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging. Oxid Med Cell Longev. 2019;2019:3849692.
  10. Liu SZ, Ali AS, Campbell MD, Kilroy K, Shankland EG, Roshanravan B, et al. Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly. J Cachexia Sarcopenia Muscle. 2018;9:826–33.
  11. Malmsten CL, Lignell A. Dietary Supplementation with Astaxanthin-Rich Algal Meal Improves Strength Endurance–A Double Blind Placebo Controlled Study on Male Students–. Carotenoid Sci. 2008;13:20–2.
  12. Fleischmann C, Horowitz M, Yanovich R, Raz H, Heled Y. Asthaxanthin Improves Aerobic Exercise Recovery Without Affecting Heat Tolerance in Humans. Front Sports Act Living. 2019;1:17.
  13. Djordjevic B, Baralic I, Kotur-Stevuljevic J, Stefanovic A, Ivanisevic J, Radivojevic N, et al. Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players. J Sports Med Phys Fitness. 2012;52:382–92.
  14. Filler K, Lyon D, Bennett J, McCain N, Elswick R, Lukkahatai N, et al. Association of Mitochondrial Dysfunction and Fatigue: A Review of the Literature. BBA Clin. 2014;1:12–23.
  15. Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, et al. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell. 2006;23:607–18.
  16. Kerner J, Yohannes E, Lee K, Virmani A, Koverech A, Cavazza C, et al. Acetyl-L-carnitine increases mitochondrial protein acetylation in the aged rat heart. Mech Ageing Dev. 2015;145:39–50.
  17. Rosca MG, Lemieux H, Hoppel CL. Mitochondria in the elderly: Is acetylcarnitine a rejuvenator? Adv Drug Deliv Rev. 2009;61:1332–42.
  18. Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, Koverech A, et al. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008;46:181–90.
  19. Zdzisińska B, Żurek A, Kandefer-Szerszeń M. Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use. Arch Immunol Ther Exp . 2017;65:21–36.
  20. Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther . 2016;24:1–8.
  21. Harrison AP, Pierzynowski SG. Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art–review article. J Physiol Pharmacol. 2008;59 Suppl 1:91–106.
  22. Asadi Shahmirzadi A, Edgar D, Liao C-Y, Hsu Y-M, Lucanic M, Asadi Shahmirzadi A, et al. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab. 2020;32:447–56.e6.
  23. Demidenko O, Barardo D, Budovskii V, Finnemore R, Palmer FR, Kennedy BK, et al. Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging . 2021;13:24485–99.
  24. Walsh B, Tonkonogi M, Söderlund K, Hultman E, Saks V, Sahlin K. The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle. J Physiol. 2001;537:971–8.
  25. Barbieri E, Guescini M, Calcabrini C, Vallorani L, Diaz AR, Fimognari C, et al. Creatine Prevents the Structural and Functional Damage to Mitochondria in Myogenic, Oxidatively Stressed C2C12 Cells and Restores Their Differentiation Capacity. Oxid Med Cell Longev. 2016;2016:5152029.
  26. Sestili P, Barbieri E, Martinelli C, Battistelli M, Guescini M, Vallorani L, et al. Creatine supplementation prevents the inhibition of myogenic differentiation in oxidatively injured C2C12 murine myoblasts. Mol Nutr Food Res. 2009;53:1187–204.
  27. Sestili P, Barbieri E, Stocchi V. Effects of Creatine in Skeletal Muscle Cells and in Myoblasts Differentiating Under Normal or Oxidatively Stressing Conditions. Mini Rev Med Chem. 2016;16:4–11.
  28. Dempsey RL, Mazzone MF, Meurer LN. Does oral creatine supplementation improve strength? A meta-analysis. J Fam Pract. 2002;51:945–51.
  29. Branch JD. Effect of creatine supplementation on body composition and performance: a meta-analysis. Int J Sport Nutr Exerc Metab. 2003;13:198–226.
  30. Lanhers C, Pereira B, Naughton G, Trousselard M, Lesage F-X, Dutheil F. Creatine Supplementation and Lower Limb Strength Performance: A Systematic Review and Meta-Analyses. Sports Med. 2015;45:1285–94.
  31. Lanhers C, Pereira B, Naughton G, Trousselard M, Lesage F-X, Dutheil F. Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis. Sports Med. 2017;47:163–73.
  32. Chilibeck PD, Kaviani M, Candow DG, Zello GA. Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis. Open Access J Sports Med. 2017;8:213–26.
  33. Filler K, Lyon D, Bennett J, McCain N, Elswick R, Lukkahatai N, et al. Association of Mitochondrial Dysfunction and Fatigue: A Review of the Literature. BBA Clin. 2014;1:12–23.
  34. Cordero MD, Moreno-Fernández AM, deMiguel M, Bonal P, Campa F, Jiménez-Jiménez LM, et al. Coenzyme Q10 distribution in blood is altered in patients with fibromyalgia. Clin Biochem. 2009;42:732–5.
  35. Di Pierro F, Rossi A, Consensi A, Giacomelli C, Bazzichi L. Role for a water-soluble form of CoQ10 in female subjects affected by fibromyalgia. A preliminary study. Clin Exp Rheumatol. 2017;35 Suppl 105:20–7.
  36. Cordero MD, Alcocer-Gómez E, de Miguel M, Culic O, Carrión AM, Alvarez-Suarez JM, et al. Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia? Antioxid Redox Signal. 2013;19:1356–61.
  37. Jafari M, Mousavi SM, Asgharzadeh A, Yazdani N. Coenzyme Q10 in the treatment of heart failure: A systematic review of systematic reviews. Indian Heart J. 2018;70 Suppl 1:S111–7.
  38. DiNicolantonio JJ, Bhutani J, McCarty MF, O’Keefe JH. Coenzyme Q10 for the treatment of heart failure: a review of the literature. Open Heart. 2015;2:e000326.
  39. Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial. Nutr Neurosci. 2016;19:138–43.
  40. Sanoobar M, Eghtesadi S, Azimi A, Khalili M, Khodadadi B, Jazayeri S, et al. Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial. Nutr Neurosci. 2015;18:169–76.
  41. Castro-Marrero J, Cordero MD, Segundo MJ, Sáez-Francàs N, Calvo N, Román-Malo L, et al. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? Antioxid Redox Signal. 2015;22:679–85.
  42. Fukuda S, Nojima J, Kajimoto O, Yamaguti K, Nakatomi Y, Kuratsune H, et al. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome. Biofactors. 2016;42:431–40.
  43. Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, et al. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. 2008;24:293–9.
  44. Castro-Marrero J, Sáez-Francàs N, Segundo MJ, Calvo N, Faro M, Aliste L, et al. Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial. Clin Nutr. 2016;35:826–34.
  45. Mizuno K, Sasaki AT, Watanabe K, Watanabe Y. Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals. Nutrients [Internet]. 2020;12. Available from: http://dx.doi.org/10.3390/nu12061640
  46. Sarmiento A, Diaz-Castro J, Pulido-Moran M, Moreno-Fernandez J, Kajarabille N, Chirosa I, et al. Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial. Biofactors. 2016;42:612–22.
  47. Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009;1790:1149–60.
  48. Savitha S, Sivarajan K, Haripriya D, Kokilavani V, Panneerselvam C. Efficacy of levo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging. Clin Nutr. 2005;24:794–800.
  49. Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res. 2009;34:755–63.
  50. Liu J, Killilea DW, Ames BN. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A. 2002;99:1876–81.
  51. Pershadsingh HA. Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome. Expert Opin Investig Drugs. 2007;16:291–302.
  52. Chen W-L, Kang C-H, Wang S-G, Lee H-M. α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase. Diabetologia. 2012;55:1824–35.
  53. Carbonelli MG, Di Renzo L, Bigioni M, Di Daniele N, De Lorenzo A, Fusco MA. Alpha-lipoic acid supplementation: a tool for obesity therapy? Curr Pharm Des. 2010;16:840–6.
  54. Koh EH, Lee WJ, Lee SA, Kim EH, Cho EH, Jeong E, et al. Effects of alpha-lipoic Acid on body weight in obese subjects. Am J Med. 2011;124:85.e1–8.
  55. Li N, Yan W, Hu X, Huang Y, Wang F, Zhang W, et al. Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial. Clin Endocrinol . 2017;86:680–7.
  56. Breithaupt-Grögler K, Niebch G, Schneider E, Erb K, Hermann R, Blume HH, et al. Dose-proportionality of oral thioctic acid–coincidence of assessments via pooled plasma and individual data. Eur J Pharm Sci. 1999;8:57–65.
  57. Huxtable RJ. Physiological actions of taurine. Physiol Rev. 1992;72:101–63.
  58. Fakruddin M, Wei F-Y, Suzuki T, Asano K, Kaieda T, Omori A, et al. Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease. Cell Rep. 2018;22:482–96.
  59. Hansen SH, Andersen ML, Cornett C, Gradinaru R, Grunnet N. A role for taurine in mitochondrial function. J Biomed Sci. 2010;17 Suppl 1:S23.
  60. Hansen SH, Andersen ML, Birkedal H, Cornett C, Wibrand F. The important role of taurine in oxidative metabolism. Adv Exp Med Biol. 2006;583:129–35.
  61. Jong CJ, Azuma J, Schaffer S. Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids. 2012;42:2223–32.
  62. Schaffer S, Kim HW. Effects and Mechanisms of Taurine as a Therapeutic Agent. Biomol Ther . 2018;26:225–41.
  63. Ripps H, Shen W. Review: taurine: a “very essential” amino acid. Mol Vis. 2012;18:2673–86.
  64. Maleki V, Mahdavi R, Hajizadeh-Sharafabad F, Alizadeh M. The effects of taurine supplementation on oxidative stress indices and inflammation biomarkers in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Diabetol Metab Syndr. 2020;12:9.
  65. Rosa FT, Freitas EC, Deminice R, Jordão AA, Marchini JS. Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study. Eur J Nutr. 2014;53:823–30.
  66. Xiao C, Giacca A, Lewis GF. Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men. Diabetologia. 2008;51:139–46.
  67. Waldron M, Patterson SD, Tallent J, Jeffries O. The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis. Sports Med. 2018;48:1247–53.
  68. Swaminathan R. Magnesium metabolism and its disorders. Clin Biochem Rev. 2003;24:47–66.
  69. Igamberdiev AU, Kleczkowski LA. Optimization of ATP synthase function in mitochondria and chloroplasts via the adenylate kinase equilibrium. Front Plant Sci. 2015;6:10.
  70. Pilchova I, Klacanova K, Tatarkova Z, Kaplan P, Racay P. The Involvement of Mg2+ in Regulation of Cellular and Mitochondrial Functions. Oxid Med Cell Longev. 2017;2017:6797460.
  71. Heber D. Pomegranate Ellagitannins. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2012.
  72. Ismail T, Calcabrini C, Diaz AR, Fimognari C, Turrini E, Catanzaro E, et al. Ellagitannins in Cancer Chemoprevention and Therapy. Toxins [Internet]. 2016;8. Available from: http://dx.doi.org/10.3390/toxins8050151
  73. Andreux PA, Blanco-Bose W, Ryu D, Burdet F, Ibberson M, Aebischer P, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019;1:595–603.
  74. Tan S, Yu CY, Sim ZW, Low ZS, Lee B, See F, et al. Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy. Sci Rep. 2019;9:727.
  75. Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-Dit-Félix AA, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med. 2016;22:879–88.
  76. Torregrosa-García A, Ávila-Gandía V, Luque-Rubia AJ, Abellán-Ruiz MS, Querol-Calderón M, López-Román FJ. Pomegranate Extract Improves Maximal Performance of Trained Cyclists after an Exhausting Endurance Trial: A Randomised Controlled Trial. Nutrients [Internet]. 2019;11. Available from: http://dx.doi.org/10.3390/nu11040721
  77. Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr. 2004;23:423–33.
  78. Davidson MH, Maki KC, Dicklin MR, Feinstein SB, Witchger M, Bell M, et al. Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease. Am J Cardiol. 2009;104:936–42.
  79. Basu A, Newman ED, Bryant AL, Lyons TJ, Betts NM. Pomegranate polyphenols lower lipid peroxidation in adults with type 2 diabetes but have no effects in healthy volunteers: a pilot study. J Nutr Metab. 2013;2013:708381.
  80. Shintani H, Ashida H, Shintani T. Shifting the focus of d-glucosamine from a dietary supplement for knee osteoarthritis to a potential anti-aging drug. Human Nutrition & Metabolism. 2021;26:200134.
  81. Li Z-H, Gao X, Chung VC, Zhong W-F, Fu Q, Lv Y-B, et al. Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study. Ann Rheum Dis. 2020;79:829–36.
  82. Ma H, Li X, Sun D, Zhou T, Ley SH, Gustat J, et al. Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank. BMJ. 2019;365:l1628.
  83. Bell GA, Kantor ED, Lampe JW, Shen DD, White E. Use of glucosamine and chondroitin in relation to mortality. Eur J Epidemiol. 2012;27:593–603.
  84. Pocobelli G, Kristal AR, Patterson RE, Potter JD, Lampe JW, Kolar A, et al. Total mortality risk in relation to use of less-common dietary supplements. Am J Clin Nutr. 2010;91:1791–800.
  85. Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, et al. D-Glucosamine supplementation extends life span of nematodes and of ageing mice. Nat Commun. 2014;5:3563.
  86. Shintani T, Kosuge Y, Ashida H. Glucosamine Extends the Lifespan of Caenorhabditis elegans via Autophagy Induction. J Appl Glycosci . 2018;65:37–43.
  87. Singhal K, Raj N, Gupta K, Singh S. Probable benefits of green tea with genetic implications. J Oral Maxillofac Pathol. 2017;21:107–14.
  88. Suzuki Y, Miyoshi N, Isemura M. Health-promoting effects of green tea. Proc Jpn Acad Ser B Phys Biol Sci. 2012;88:88–101.
  89. Chacko SM, Thambi PT, Kuttan R, Nishigaki I. Beneficial effects of green tea: a literature review. Chin Med. 2010;5:13.
  90. Ortiz-López L, Márquez-Valadez B, Gómez-Sánchez A, Silva-Lucero MDC, Torres-Pérez M, Téllez-Ballesteros RI, et al. Green tea compound epigallo-catechin-3-gallate (EGCG) increases neuronal survival in adult hippocampal neurogenesis in vivo and in vitro. Neuroscience. 2016;322:208–20.
  91. Pervin M, Unno K, Ohishi T, Tanabe H, Miyoshi N, Nakamura Y. Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases. Molecules [Internet]. 2018;23. Available from: http://dx.doi.org/10.3390/molecules23061297
  92. Babu PVA, Liu D. Green tea catechins and cardiovascular health: an update. Curr Med Chem. 2008;15:1840–50.
  93. Bhardwaj P, Khanna D. Green tea catechins: defensive role in cardiovascular disorders. Chin J Nat Med. 2013;11:345–53.
  94. Rains TM, Agarwal S, Maki KC. Antiobesity effects of green tea catechins: a mechanistic review. J Nutr Biochem. 2011;22:1–7.
  95. Hursel R, Westerterp-Plantenga MS. Catechin- and caffeine-rich teas for control of body weight in humans. Am J Clin Nutr. 2013;98:1682S – 1693S.
  96. Hursel R, Viechtbauer W, Westerterp-Plantenga MS. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes . 2009;33:956–61.
  97. Cooper R, Morré DJ, Morré DM. Medicinal benefits of green tea: part II. review of anticancer properties. J Altern Complement Med. 2005;11:639–52.
  98. Lambert JD. Does tea prevent cancer? Evidence from laboratory and human intervention studies. Am J Clin Nutr. 2013;98:1667S – 1675S.
  99. Park J-H, Bae J-H, Im S-S, Song D-K. Green tea and type 2 diabetes. Integr Med Res. 2014;3:4–10.
  100. Oliveira MR de, Nabavi SF, Daglia M, Rastrelli L, Nabavi SM. Epigallocatechin gallate and mitochondria-A story of life and death. Pharmacol Res. 2016;104:70–85.
  101. Schroeder EK, Kelsey NA, Doyle J, Breed E, Bouchard RJ, Loucks FA, et al. Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons. Antioxid Redox Signal. 2009;11:469–80.
  102. Most J, Timmers S, Warnke I, Jocken JW, van Boekschoten M, de Groot P, et al. Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial. Am J Clin Nutr. 2016;104:215–27.
  103. Jurgens TM, Whelan AM, Killian L, Doucette S, Kirk S, Foy E. Green tea for weight loss and weight maintenance in overweight or obese adults. Cochrane Database Syst Rev. 2012;12:CD008650.
  104. Baladia E, Basulto J, Manera M, Martínez R, Calbet D. [Effect of green tea or green tea extract consumption on body weight and body composition; systematic review and meta-analysis]. Nutr Hosp. 2014;29:479–90.
  105. Zhong X, Zhang T, Liu Y, Wei X, Zhang X, Qin Y, et al. Short-term weight-centric effects of tea or tea extract in patients with metabolic syndrome: a meta-analysis of randomized controlled trials. Nutr Diabetes. 2015;5:e160.
  106. Vázquez Cisneros LC, López-Uriarte P, López-Espinoza A, Navarro Meza M, Espinoza-Gallardo AC, Guzmán Aburto MB. Effects of green tea and its epigallocatechin (EGCG) content on body weight and fat mass in humans: a systematic review. Nutr Hosp. 2017;34:731–7.
  107. Hibi M, Takase H, Iwasaki M, Osaki N, Katsuragi Y. Efficacy of tea catechin-rich beverages to reduce abdominal adiposity and metabolic syndrome risks in obese and overweight subjects: a pooled analysis of 6 human trials. Nutr Res. 2018;55:1–10.
  108. Lee HS, Lim S-M, Jung JI, Kim SM, Lee JK, Kim YH, et al. Gynostemma Pentaphyllum Extract Ameliorates High-Fat Diet-Induced Obesity in C57BL/6N Mice by Upregulating SIRT1. Nutrients [Internet]. 2019;11. Available from: http://dx.doi.org/10.3390/nu11102475
  109. Gauhar R, Hwang S-L, Jeong S-S, Kim J-E, Song H, Park DC, et al. Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase. Biotechnol Lett. 2012;34:1607–16.
  110. Nguyen PH, Gauhar R, Hwang SL, Dao TT, Park DC, Kim JE, et al. New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum. Bioorg Med Chem. 2011;19:6254–60.
  111. Park S-H, Huh T-L, Kim S-Y, Oh M-R, Tirupathi Pichiah PB, Chae S-W, et al. Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): a randomized, double-blind, placebo-controlled trial. Obesity . 2014;22:63–71.
  112. Huyen VTT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42:353–7.
  113. Chou S-C, Chen K-W, Hwang J-S, Lu W-T, Chu Y-Y, Lin J-D, et al. The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease. Altern Ther Health Med. 2006;12:34–9.
  114. Singh N, Bhalla M, de Jager P, Gilca M. An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. 2011;8:208–13.
  115. Pratte MA, Nanavati KB, Young V, Morley CP. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med. 2014;20:901–8.
  116. Andrade C. Ashwagandha for anxiety disorders. World J. Biol. Psychiatry. 2009. p. 686–7.
  117. Zahiruddin S, Basist P, Parveen A, Parveen R, Khan W, Gaurav, et al. Ashwagandha in brain disorders: A review of recent developments. J Ethnopharmacol. 2020;257:112876.
  118. Lee D-H, Ahn J, Jang Y-J, Seo H-D, Ha T-Y, Kim MJ, et al. Withania somnifera Extract Enhances Energy Expenditure via Improving Mitochondrial Function in Adipose Tissue and Skeletal Muscle. Nutrients [Internet]. 2020;12. Available from: http://dx.doi.org/10.3390/nu12020431
  119. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine . 2019;98:e17186.
  120. Lopresti AL, Drummond PD, Smith SJ. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males. Am J Mens Health. 2019;13:1557988319835985.
  121. Deshpande A, Irani N, Balkrishnan R, Benny IR. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Med. 2020;72:28–36.
  122. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus. 2019;11:e6466.
  123. Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus. 2019;11:e5797.
  124. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34:255–62.
  125. Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. Curr Clin Pharmacol [Internet]. 2020; Available from: http://dx.doi.org/10.2174/1574884715666200413120413
  126. Li X-T, Chen R, Jin L-M, Chen H-Y. Regulation on energy metabolism and protection on mitochondria of Panax ginseng polysaccharide. Am J Chin Med. 2009;37:1139–52.
  127. Huang Y, Kwan KKL, Leung KW, Yao P, Wang H, Dong TT, et al. Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: a functional comparison of different extraction solvents. J Ginseng Res. 2019;43:517–26.
  128. Jin T-Y, Rong P-Q, Liang H-Y, Zhang P-P, Zheng G-Q, Lin Y. Clinical and Preclinical Systematic Review of Panax ginseng C. A. Mey and Its Compounds for Fatigue. Front Pharmacol. 2020;11:1031.
  129. Lee N, Lee S-H, Yoo H-R, Yoo HS. Anti-Fatigue Effects of Enzyme-Modified Ginseng Extract: A Randomized, Double-Blind, Placebo-Controlled Trial. J Altern Complement Med. 2016;22:859–64.
  130. Kim H-G, Cho J-H, Yoo S-R, Lee J-S, Han J-M, Lee N-H, et al. Antifatigue Effects of Panax ginseng C.A. Meyer: A Randomised, Double-Blind, Placebo-Controlled Trial. PLoS One [Internet]. Public Library of Science; 2013 [cited 2019 Nov 25];8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629193/
  131. Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010;285:142–52.
  132. Saihara K, Kamikubo R, Ikemoto K, Uchida K, Akagawa M. Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway. Biochemistry. 2017;56:6615–25.
  133. Hwang P, Willoughby DS. Mechanisms Behind Pyrroloquinoline Quinone Supplementation on Skeletal Muscle Mitochondrial Biogenesis: Possible Synergistic Effects with Exercise. J Am Coll Nutr. 2018;37:738–48.
  134. Nakano M, Yamamoto T, Okamura H, Tsuda A, Kowatari Y. Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep. Functional Foods in Health and Disease. 2012;2:307–24.
  135. Harris CB, Chowanadisai W, Mishchuk DO, Satre MA, Slupsky CM, Rucker RB. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. J Nutr Biochem. 2013;24:2076–84.
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